RAW 264.7

Supplier: CLS cell lines service, Germany

Cat no.: 400319

Due to an infection with the Abelson-Mouse-Leukemia Virus (Ab-MLV) and an ecotropic MLV, the BAB/14 mouse had developed tumors.

The macrophage-like cells will pinocytose neutral red and will phagocytose latex beads and zymosan. They are capable of antibody dependent lysis of sheep erythrocytes and tumor cell targets.

LPS or PPD treatment for 2 days stimulates lysis of erythrocytes but not tumor cell targets.

History and Usage in Immunology

The RAW 264.7 cell line is an immortalized murine macrophage cell line, which was established from a tumor induced by the Abelson murine leukemia virus in an adult male mouse.

Since its establishment, the cell line has been widely used in immunological and biological research due to its ability to differentiate and function similarly to primary macrophages.

In immunology experiments, RAW 264.7 cells have been employed for a variety of purposes:

1. The production of nitric oxide (NO) and various cytokines in these cells can be measured as indicators of inflammatory response.

In summary, the RAW 264.7 cell line holds a significant place in immunological research.

Its versatility and robustness allow for diverse experimental applications, making it a fundamental tool in understanding macrophage biology and immune responses.

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