IL-1 alpha (Interleukin-1α), Human

Interleukin 1 alpha (IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells.

It possesses metabolic, physiological, haematopoietic activities, and plays one

of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.

1 cells proliferation.

The ED50 for this effect is <10 pg/mL. The specific activity of recombinant human IL-1 alpha is approximately >1 x108 IU/mg.

2 μm filtered solution of PBS, pH 8.0.

Avoid repeated freeze/thaw cycles.