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Croyez Bioscience Co., Ltd.Cre Recombinase mRNA is a high-performance IVT mRNA reagent designed for efficient Cre-loxP genome engineering applications, including conditional knockouts, knock-ins, and lineage tracing. Engineered with a Cap1 structure, Poly(A) tail, and modified nucleotides, it delivers strong transient expression while minimizing innate immune activation in mammalian cells.
Cre recombinase is a 38 kDa site‑specific recombinase derived from P1 bacteriophage that catalyzes precise DNA recombination between pairs of 34 bp loxP recognition sites, enabling efficient deletion, inversion, or insertion of floxed DNA segments in eukaryotic genomes. As a gold‑standard tool for genome engineering, the Cre/loxP system is widely used to perform conditional knockouts, knock‑ins, and cell‑lineage tracing in cultured cells and diverse animal models.
Cre mRNA is engineered for optimal performance. Manufactured via in vitro transcription (IVT), our mRNA features a Cap1 structure and a Poly(A) tail to mimic natural mature mRNA, ensuring superior stability and translation efficiency.
Furthermore, the incorporation of modified nucleotides significantly reduces innate immune responses, enabling high-level expression and safer application in diverse cell types.
mRNA Length 1612 nt
Base Composition N1-Me-pUTP (N1-mψ)
Concentration 1.0 mg/ mL
Cap Modification Cap 1 structure
Poly A Tail Yes
Form Liquid Buffer 1 mM sodium citrate buffer, pH 6.
4.
Storage Products can be stored at -80°C or below.
We recommend to aliquot the mRNA solution for a better storage. Avoid repeated freeze/thaw cycles.
Shipping The products are shipped on dry ice and should be avoided for freeze-thaw cycles.
Application
Gene editing
Shipping Conditions Dry ice
