Anti-APP [pT668] - 40 µL

Data sheet

Applications — Western Blot , Immunohistochemistry, Immunofluorescence

Reactivity — Human, Mouse, Rat

Conservation — +4°C / -20°C

Quantity — 40 µL

Download —  Datasheet 4BDX-1503S

More info

The anti-APP antibody [pT668] recognizes the phosphorylated threonine 668 of Amyloid Protein Precursor (APP). This antibody is suitable for Western Blot, for Immunohistochemistry and Immunofluorescence.

This polyserum was obtained by immunizing a rabbit with a 12 amino acid peptide containing the phosphorylated threonine 668 (YVDAAVTPEERH). This antibody is determined by its ability to recognize human APP phosphorylated at threonine 668.

Research Use Only Product (RUO) / Not for Diagnosis or Therapeutic Use.

Background on the anti-Tau antibody phosphorylated at threonine 668

Amyloid Protein Precursor also called APP (Gene ID: 351) is a type 1 transmembrane protein whose metabolism leads to the production of amyloid-beta peptides. In Alzheimer’s disease, amyloid peptides are the main components of amyloid deposits.

The phosphorylation of Anti-APP antibody at threonine 668 (a position corresponding to the APP695 isoform) is increased in Alzheimer’s disease and promotes amyloid-beta peptide production.

4BioDx polyclonal antibodies against APP at phosphorylated Thr-668 (4BDX-1503S) are useful tools to detect phosphorylated APP in rat, mice or human brain homogenates by western blot.

These antibodies worked greatly in immunohistochemistry and immunofuorescence protocols and they indicated neuritic processes surrounding amyloid deposits (see applications below).

The Anti-APP [pT668] antibody (Ref. 4BDX-1503S) recognizes the phosphorylated threonine 668 of Amyloid Protein Precursor (APP).

This antibody is a biomarker of neuritic processes surrounding amyloid deposits.

Applications

Western-blotting of mouse brain extracts

Immunohistochemistry of human Alzheimer disease brain

Immunofluorescence of human Alzheimer disease brain