MagRacks are designed to optimize DNA/RNA/protein preparations with magnetic micro- and nanoparticles (magnetic beads) in standard 1.5 or 2.0 ml tubes. Using MagRacks allows fast and simple isolation procedures from various biological materials. In general, magnetic beads significantly increase the speed of isolation procedure compared to classical solution- or membrane-based methods. Avoiding all centrifugation steps and replacing them by magnetic separation is the key point to process optimization and automatization of DNA/RNA isolation procedures. Magnetic racks provide fast and reliable separation of particles from a liquid phase. The particles are safely collected on the tube wall without centrifugation. In contrast, particles of nonmagnetic sorbents often separate from a pellet causing loss of isolated substances.
Caution of Strong Magnetic Field
Magnetic fields can cause damage to magnetic storage media including credit cards, magnetic data tapes and computer hard drives. Strong magnetic fields can cause implanted heart pacemakers and cardioverter defibrillators to cease operation. Keep any electronic devices at least 1 meter away from the magnet. Interaction with metallic objects may produce pinch hazards.
General transportation and operation rules
Avoid hard shocks and falls of the magnetic rack and follow precautions described above during transportation and daily work. Do not store the rack near electronic and precision mechanical devices. Wash the rack only with warm water and soap in case it becomes dirty. Do not clean it with aggressive washing liquids or abrasive materials.
Working with the magnetic rack
To separate particles, place tubes with their lids outside into the wells of the transparent top plate of the magnetic rack. Separation of particles begins immediately and proceeds very fast due to the strong magnetic field generated by the collector. When particles are collected, the liquid phase of the tubes can be removed. The tubes must remain in the rack during the whole separation process to avoid diffusion of magnetic particles into the liquid phase. To remove the liquid phase from tubes an automated aspirator is recommended but working with a regular pipette is possible as well.
Remove tubes from the magnetic rack for resuspending particles or adding new components. Particles can be resuspended outside the magnetic rack by manual pipetting, using a handheld laboratory mixer or vortexing.